25 20 15 10 5 0 No itch Mild itch CS itch CS threshold 25 20 15 10 5 0 No itch Mild itch CS itch CS threshold 10 0 % of all patients (n=211) 20 30 40 50 60 70 80 CS itch* 10 0 % of all patients (n=211) 20 30 40 50 60 70 80 CS itch* 14 12 10 8 6 4 2 0 No itch Mild itch CS itch CS threshold 14 12 10 8 6 4 2 0 No itch Mild itch CS itch CS threshold 50 40 30 20 10 0 No itch Mild itch CS itch CS threshold 50 40 30 20 10 0 No itch Mild itch CS itch CS threshold 6 4 -2 2 0 -4 -6 -8 -8 -6 -4 -2 0 2 4 6 r=0.84 p<0.0001 Change from baseline in MSS Change from baseline in MIS 6 4 -2 2 0 -4 -6 -8 -8 -6 -4 -2 0 2 4 6 r=0.84 p<0.0001 Change from baseline in MSS Change from baseline in MIS < 6 hours 6–12 hours 12–18 hours 18–23 hours All day 5-D ITCH: DURATION* 0–2 body parts 3–5 body parts 6–10 body parts 11–13 body parts 14–16 body parts 5-D ITCH: DISTRIBUTION † Legend < 6 hours 6–12 hours 12–18 hours 18–23 hours All day 5-D ITCH: DURATION* 0–2 body parts 3–5 body parts 6–10 body parts 11–13 body parts 14–16 body parts 5-D ITCH: DISTRIBUTION † Legend Fatigue Symptoms Emotional Fatigue Symptoms Emotional 10.0 7.5 5.0 2.5 0.0 Pruritus intensity in the past 7 days (‘current pruritus’ NRS) 2011 2014 2017 Survey year Archetypal disease patterns (n = 1753) Persistent low pruritus group (54%) Persistent moderate pruritus group (28%) Persistent high pruritus group (18%) 10.0 7.5 5.0 2.5 0.0 Pruritus intensity in the past 7 days (‘current pruritus’ NRS) 2011 2014 2017 Survey year Archetypal disease patterns (n = 1753) Persistent low pruritus group (54%) Persistent moderate pruritus group (28%) Persistent high pruritus group (18%) 0 No itch ≥ 1 to < 7 Mild itch* ≥ 7 Clinically significant itch † 40 35 30 25 20 15 10 5 0 PBC-40 domain score​ 0 No itch ≥ 1 to < 7 Mild itch* ≥ 7 Clinically significant itch † 40 35 30 25 20 15 10 5 0 PBC-40 domain score​ Emotional Fatigue Cognitive Symptoms Social Itch Domain 1 Emotional Fatigue Cognitive Symptoms Social Itch Domain 1 Symptom measure scores​ (range)​ 11 – 54 6 – 29 6 – 33 8 – 47 0 – 15 3 – 14 Symptom measure scores​ (range)​ 11 – 54 6 – 29 6 – 33 8 – 47 0 – 15 3 – 14 40 30 20 10 0 No itch Mild itch CS itch CS threshold 40 30 20 10 0 No itch Mild itch CS itch CS threshold 25 20 15 10 5 0 No itch Mild itch CS itch CS threshold 25 20 15 10 5 0 No itch Mild itch CS itch CS threshold 42 42 37 % 37 % 81 % 81 % 9 x 9 x 37 % 37 % 81 % 81 % RESULTS RESULTS