25
20
15
10
5
0
No itch
Mild itch
CS itch
CS threshold
25
20
15
10
5
0
No itch
Mild itch
CS itch
CS threshold
10
0
% of all patients (n=211)
20
30
40
50
60
70
80
CS itch*
10
0
% of all patients (n=211)
20
30
40
50
60
70
80
CS itch*
14
12
10
8
6
4
2
0
No itch
Mild itch
CS itch
CS threshold
14
12
10
8
6
4
2
0
No itch
Mild itch
CS itch
CS threshold
50
40
30
20
10
0
No itch
Mild itch
CS itch
CS threshold
50
40
30
20
10
0
No itch
Mild itch
CS itch
CS threshold
6
4
-2
2
0
-4
-6
-8
-8
-6
-4
-2
0
2
4
6
r=0.84
p<0.0001
Change from baseline in MSS
Change from baseline in MIS
6
4
-2
2
0
-4
-6
-8
-8
-6
-4
-2
0
2
4
6
r=0.84
p<0.0001
Change from baseline in MSS
Change from baseline in MIS
< 6 hours
6–12 hours
12–18 hours
18–23 hours
All day
5-D ITCH: DURATION*
0–2 body parts
3–5 body parts
6–10 body parts
11–13 body parts
14–16 body parts
5-D ITCH: DISTRIBUTION
â€
Legend
< 6 hours
6–12 hours
12–18 hours
18–23 hours
All day
5-D ITCH: DURATION*
0–2 body parts
3–5 body parts
6–10 body parts
11–13 body parts
14–16 body parts
5-D ITCH: DISTRIBUTION
â€
Legend
Fatigue
Symptoms
Emotional
Fatigue
Symptoms
Emotional
10.0
7.5
5.0
2.5
0.0
Pruritus intensity in the past 7 days
(‘current pruritus’ NRS)
2011
2014
2017
Survey year
Archetypal disease patterns (n = 1753)
Persistent low
pruritus group (54%)
Persistent moderate
pruritus group (28%)
Persistent high
pruritus group (18%)
10.0
7.5
5.0
2.5
0.0
Pruritus intensity in the past 7 days
(‘current pruritus’ NRS)
2011
2014
2017
Survey year
Archetypal disease patterns (n = 1753)
Persistent low
pruritus group (54%)
Persistent moderate
pruritus group (28%)
Persistent high
pruritus group (18%)
0
No itch
≥ 1 to < 7
Mild itch*
≥ 7
Clinically
significant itch
â€
40
35
30
25
20
15
10
5
0
PBC-40 domain score​
0
No itch
≥ 1 to < 7
Mild itch*
≥ 7
Clinically
significant itch
â€
40
35
30
25
20
15
10
5
0
PBC-40 domain score​
Emotional
Fatigue
Cognitive
Symptoms
Social
Itch
Domain
1
Emotional
Fatigue
Cognitive
Symptoms
Social
Itch
Domain
1
Symptom measure
scores​ (range)​
11 – 54
6 – 29
6 – 33
8 – 47
0 – 15
3 – 14
Symptom measure
scores​ (range)​
11 – 54
6 – 29
6 – 33
8 – 47
0 – 15
3 – 14
40
30
20
10
0
No itch
Mild itch
CS itch
CS threshold
40
30
20
10
0
No itch
Mild itch
CS itch
CS threshold
25
20
15
10
5
0
No itch
Mild itch
CS itch
CS threshold
25
20
15
10
5
0
No itch
Mild itch
CS itch
CS threshold
42
42
37
%
37
%
81
%
81
%
9
x
9
x
37
%
37
%
81
%
81
%
RESULTS
RESULTS